During bronchoscopy, a physician uses the endobronchial video to help navigate and observe the inner airways of a patient’s lungs for lung cancer assessment. After the procedure is completed, the video typically contains a significant number of uninformative frames. A video frame is uninformative when it is too dark, too blurry, or indistinguishable due to a build-up of mucus, blood, or water within the airways. We develop a robust and automatic system, consisting of two distinct approaches, to classify each frame in an endobronchial video sequence as informative or uninformative. Our first approach, referred as the Classifier Approach, focuses on using image-processing techniques and a support vector machine, while our second approach, the Deep-Learning Approach, draws upon a convolutional neural network for video frame classification. Using the Classifier Approach, we achieved an accuracy of 78.8%, a sensitivity of 93.9%, and a specificity of 62.8%. The Deep-Learning Approach, gave slightly improved performance, with an accuracy of 87.3%, a sensitivity of 87.1%, and a specificity of 87.6%.